Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound.
Tiffany G ChanSophie V MorseMatthew J CoppingJames J ChoiRamon VilarPublished in: ChemMedChem (2018)
Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood-brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA-coated gold nanoparticles to specific locations in the brains of mice.
Keyphrases
- gold nanoparticles
- circulating tumor
- cell free
- single molecule
- reduced graphene oxide
- high resolution
- blood brain barrier
- nucleic acid
- deep learning
- resting state
- white matter
- sensitive detection
- high fat diet induced
- type diabetes
- circulating tumor cells
- walled carbon nanotubes
- functional connectivity
- multiple sclerosis
- cerebral ischemia
- skeletal muscle
- wild type
- photodynamic therapy