Predictors of response to insulin therapy in youth with poorly-controlled type 2 diabetes in the TODAY trial.
Fida BachaLaure El GhormliSilva A ArslanianPhilip S ZeitlerLori M B LaffelLorraine E Levitt KatzRachelle GandicaNancy T ChangJennifer E SpragueSarah A Macleishnull nullPublished in: Pediatric diabetes (2019)
Response to add-on insulin was highly variable among youth in TODAY. Greater insulin sensitivity and higher adiponectin concentrations at randomization were associated with improved glycemic control after initiation of insulin. Due to limited information on adherence to insulin injections, the roles of adherence to the prescribed insulin regimen or psychosocial factors are unknown.