Mutation profile of high-grade appendiceal mucinous neoplasm.

Xiaoyan LiaoVera VavinskayaKatherine SunYansheng HaoXiaodong LiMark ValasekRuliang XuAlexandros D PolydoridesJane HouldsworthNoam Harpaz

Published in: Histopathology (2019)

HAMN and LAMN share high rates of KRAS and GNAS co-mutations supporting a common histogenesis and distinguishing them from MACA. Acquisition of TP53 or ATM mutations by HAMN may drive its progression to a more advanced phenotype.

Keyphrases

low grade
high grade
dna repair
wild type
oxidative stress