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Mutation profile of high-grade appendiceal mucinous neoplasm.

Xiaoyan LiaoVera VavinskayaKatherine SunYansheng HaoXiaodong LiMark ValasekRuliang XuAlexandros D PolydoridesJane HouldsworthNoam Harpaz
Published in: Histopathology (2019)
HAMN and LAMN share high rates of KRAS and GNAS co-mutations supporting a common histogenesis and distinguishing them from MACA. Acquisition of TP53 or ATM mutations by HAMN may drive its progression to a more advanced phenotype.
Keyphrases
  • low grade
  • high grade
  • dna repair
  • wild type
  • oxidative stress