Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource.
Christina KapizioniRofaida DesokiDanielle LamKarthiha BalendranEman Al-SulaisSreedhar SubramanianJoanna E RimmerJuan De La Revilla NegroHolly PaveyLaetitia PeleJohanne BrooksGordon W MoranPeter M IrvingJimmy K LimdiChristopher A Lambnull nullMiles ParkesTimothy RainePublished in: Journal of Crohn's & colitis (2023)
We provide real-world evidence to guide biologic selection and sequencing in a range of common scenarios. Our findings challenge current guidelines regarding drug selection after loss of response to first anti-TNF.