Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource.

Christina KapizioniRofaida DesokiDanielle LamKarthiha BalendranEman Al-SulaisSreedhar SubramanianJoanna E RimmerJuan De La Revilla NegroHolly PaveyLaetitia PeleJohanne BrooksGordon W MoranPeter M IrvingJimmy K LimdiChristopher A Lambnull nullMiles ParkesTimothy Raine

Published in: Journal of Crohn's & colitis (2023)

We provide real-world evidence to guide biologic selection and sequencing in a range of common scenarios. Our findings challenge current guidelines regarding drug selection after loss of response to first anti-TNF.

Keyphrases

rheumatoid arthritis
end stage renal disease
single cell
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
clinical practice
ulcerative colitis
emergency department
patient reported outcomes