Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain.
Rahat UllahMyeung Hoon JoMuhammad RiazSayed Ibrar AlamKamran SaeedWaqar AliInayat Ur RehmanMuhammad IkramMyeong Ok KimPublished in: Journal of neuroinflammation (2020)
Our findings demonstrate that Gly-mediated deactivation of the JNK signaling pathway underlies the neuroprotective effect of Gly, which reverses D-gal-induced oxidative stress, apoptotic neurodegeneration, neuroinflammation, synaptic dysfunction, and memory impairment. Therefore, we suggest that Gly (an amino acid) is a safe and promising neurotherapeutic candidate that might be used for age-related neurodegenerative diseases.
Keyphrases
- amino acid
- signaling pathway
- cerebral ischemia
- cell death
- working memory
- induced apoptosis
- pi k akt
- diabetic rats
- high glucose
- traumatic brain injury
- oxidative stress
- brain injury
- hydrogen peroxide
- subarachnoid hemorrhage
- epithelial mesenchymal transition
- lipopolysaccharide induced
- cognitive impairment
- lps induced
- tyrosine kinase
- protein kinase
- drug induced
- inflammatory response
- cell proliferation