Zika virus-induced brain malformations in chicken embryos.
Gabriela Elis WachholzAna Paula Muterle VarelaThais Fumaco TeixeiraSophia Martins Simon de MatosPaula Rigon da Luz SosterFernanda Sales Luiz ViannaDiogo Onofre Gomes de SouzaPaulo Michel RoeheLavínia Schuler-FacciniLucas Rosa FragaPublished in: Birth defects research (2020)
We found that ZIKV exposed embryos presented a high prevalence of mortality and central nervous system (CNS) abnormalities in a dose-dependent manner. The phenotype was more evident 4 days postinfection, when the viral load quantification reached a peak.