Influence of ABCB1 C3435T and C1236T gene polymorphisms on tumour response to docetaxel-based neo-adjuvant chemotherapy in locally advanced breast cancer patients of South India.
Rekha PriyadarshiniGerard Marshall RajSmita KayalAnanthakrishnan RameshDeepak Gopal ShewadePublished in: Journal of clinical pharmacy and therapeutics (2019)
The tumour response to docetaxel was significantly influenced by the SNP C1236T of ABCB1 gene coding for the P-gp. However, when adjusted for other non-genetic factors, neither of the ABCB1 variants were found to be associated with tumour response to docetaxel-based NACT in LABC patients of South India.
Keyphrases
- locally advanced
- genome wide
- copy number
- rectal cancer
- neoadjuvant chemotherapy
- end stage renal disease
- squamous cell carcinoma
- radiation therapy
- newly diagnosed
- phase ii study
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- dna methylation
- gene expression
- lymph node
- patient reported
- high density
- open label