Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.

I I BadshahS BrownL WeibelA RoseB WayN SebireG InmanJ HarperRyan F L O'Shaughnessy

Published in: The British journal of dermatology (2019)

We demonstrate that cell-intrinsic changes in the LM fibroblast secretome lead to changes observed in the disease, and that secretome modulation could be a viable therapeutic approach in the treatment of LM.

Keyphrases

single cell
cell therapy
stem cells
bone marrow
mesenchymal stem cells
neural network
smoking cessation