Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor.

Teita AsanoKen-Ichiro TanakaArisa TadaHikaru ShimamuraRikako TanakaHiroki MaruokaTohru MizushimaMitsuko Takenaga

Published in: British journal of pharmacology (2017)

Our results indicate that chlorpromazine ameliorates visceral hypersensitivity and that the 5-HT2A receptor is a potential therapeutic target for treating abdominal pain and discomfort in IBS.

Keyphrases

abdominal pain
insulin resistance
drug induced
mouse model
type diabetes
metabolic syndrome
climate change