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Recommendations and Associated Levels of Evidence for Statin Use in Primary Prevention of Cardiovascular Disease: A Comparison at Population Level of the American Heart Association/American College of Cardiology/Multisociety, US Preventive Services Task Force, Department of Veterans Affairs/Department of Defense, Canadian Cardiovascular Society, and European Society of Cardiology/European Atherosclerosis Society Clinical Practice Guidelines.

Jelena PavlovićPhilip GreenlandOscar H FrancoMaryam KavousiMohammad Kamran IkramJaap W DeckersMohammad Arfan IkramMaarten J G Leening
Published in: Circulation. Cardiovascular quality and outcomes (2021)
Sensitivity, specificity, and numbers needed to treat at 10 years for assigned LOE/class varied greatly among 5 CVD prevention guidelines. The level of variability seems to be driven by differences in how the evidence is graded and translated into LOE/class underlying the treatment recommendations by different professional societies. Efforts towards harmonizing evidence grading systems for clinical guidelines in primary prevention of CVD may reduce ambiguity and reinforce updated evidence-based recommendations.
Keyphrases
  • cardiovascular disease
  • clinical practice
  • healthcare
  • cardiac surgery
  • heart failure
  • mental health
  • metabolic syndrome
  • acute kidney injury
  • thoracic surgery
  • replacement therapy