FLCN-regulated miRNAs suppressed reparative response in cells and pulmonary lesions of Birt-Hogg-Dubé syndrome.

Haiyan MinDehua MaWei ZouYongzheng WuYibing DingChengchu ZhuAnqi LinShiyu SongQiao LiangBaofu ChenBin ZhangYueming WanMinhua YeYanqing PanYanting WenLong YiQian Gao

Published in: Thorax (2020)

The upregulation of miR-424-5p and let-7d-5p by FLCN deficiency occurred in epithelial cells and marked the PSP-BHD condition, which contributed to a focused degenerative pathology in the lung of PSP-BHD patients.

Keyphrases

end stage renal disease
ejection fraction
induced apoptosis
newly diagnosed
chronic kidney disease
signaling pathway
cell cycle arrest
transcription factor
cell proliferation
oxidative stress
cell death
long non coding rna
smoking cessation