Login / Signup

Biomimetic Total Syntheses of Ergot Alkaloids via Decarboxylative Giese Coupling.

Yuhua GeHang WangHua-Nan WangShu-Sheng YuRui YangXingyue ChenQin ZhaoGang Chen
Published in: Organic letters (2020)
Biomimetic total syntheses of Festuclavine and Pyroclavine were achieved by a sequential radical coupling. The key steps include intramolecular decarboxylative Giese reaction to form the central C ring and 4-nitrobenzenesulfonyl (Ns)-directed indole C4-H olefination to introduce the indole C4 component. In addition, D-ring formation was completed by decarboxylative alkenylation and intramolecular SN2 reaction.
Keyphrases
  • visible light
  • electron transfer
  • room temperature
  • energy transfer
  • tissue engineering
  • dengue virus
  • ionic liquid