Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus.

Wenjuan TanKang GeLei ShenHongdong WangWen-Huan FengXitai SunXuehui ChuDalong ZhuHongli YinYan Bi

Published in: Diabetes/metabolism research and reviews (2023)

Our data implicate an increased Th1-like MAIT cell subset in the liver of newly diagnosed T2DM subjects, which induces hyperglycemia by promoting hepatic gluconeogenesis. It provides novel insights into the immune regulation of metabolic homeostasis. This article is protected by copyright. All rights reserved.

Keyphrases

newly diagnosed
single cell
cell therapy
electronic health record
big data
stem cells
machine learning
bone marrow
skeletal muscle
glycemic control