Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models.
Jessica BordiniFederica MorisiAngela Rita EliaPaolo SantambrogioAlessia PaganiVito CucchiaraPaolo GhiaMaria Teresa Sabrina BertilaccioAlberto BrigantiClara CamaschellaAlessandro CampanellaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our models allow us to dissect the direct iron effect on cancer cells. We demonstrate the proof of principle that iron toxicity inhibits prostate cancer cell proliferation, proposing a novel tool to strengthen antiandrogen treatment efficacy.