The COL5A3 and MMP9 genes interact in eczema susceptibility.
P Margaritte-JeanninM-C BabronC LapriseN LavielleC SarnowskiM BrossardM MoffattV Gagné-OuelletA EtchetoM LathropJocelyne JustW O CooksonE BouzigonF DemenaisMarie-Hélène DizierPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
This study identified significant interaction between two new genes, COL5A3 and MMP9, which may be accounted for by a degradation of COL5A3 by MMP9 influencing eczema susceptibility. Further confirmation of this interaction as well as functional studies is needed to better understand the role of these genes in eczema.