Biosensors and biomarkers for determining gestational diabetes mellitus and jaundice in children.
Shuangqin PengQin WangGuoping XiongSubash C B GopinathGang LeiPublished in: Biotechnology and applied biochemistry (2021)
Gestational diabetes and jaundice are the correlated diseases predominantly found in mother and newborn child. Jaundice is a neonatal complication with an increased risk when mother has gestational diabetes. Mothers with diabetes at an early stage of gestational age are at higher risk for hyperbilirubinemia (jaundice) and hypoglycemia. So, it is mandatory to monitor the condition of diabetes and jaundice during the pregnancy period for a healthy child and safest delivery. On the other hand, nanotechnology has displayed a rapid advancement that can be implemented to overcome these issues. The development of high-performance diagnosis using appropriate biomarkers provides their efficacy in the detection gestational diabetes and jaundice. This review covers the aspects from a fast-developing field to generate nanosensors in the nanosized dimensions for the applications to overcome these complications by coupling diagnostics with biomarkers. Further, the serum-based biomarkers have been discussed for these inborn complications and also the diagnosis with the current trend.
Keyphrases
- pregnancy outcomes
- type diabetes
- early stage
- gestational age
- preterm birth
- cardiovascular disease
- glycemic control
- mental health
- pregnant women
- risk factors
- birth weight
- squamous cell carcinoma
- young adults
- radiation therapy
- adipose tissue
- insulin resistance
- skeletal muscle
- lymph node
- label free
- sensitive detection
- electron transfer