Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors.
John A GroutPhilémon SirvenAndrew M LeaderShrisha MaskeyEglantine HectorIsabelle PuisieuxFiona SteffanEvan ChengNavpreet TungMathieu MaurinRomain VaineauLea KarpfMartin PlaudAnne-Laure BegueKoushik GaneshJérémy MespleMaría Casanova-AcebesAlexandra TabachnikovaShilpa KeerthivasanAlona LanskyJessica Le BerichelLaura WalkerAdeeb H RahmanSacha GnjaticNicolas GirardMarine LefevreDiane DamotteJulien AdamJerome Christophe MartinAndrea WolfRaja M FloresMary Beth BeasleyRachana N PradhanSören MüllerThomas U MarronShannon J TurleyMiriam MeradEphraim KenigsbergHélène SalmonPublished in: Cancer discovery (2022)
The cellular and molecular programs driving T-cell marginalization in solid tumors remain unclear. Here, we describe two CAF populations associated with T-cell exclusion in human lung tumors. We demonstrate the importance of pairing molecular and spatial analysis of the tumor microenvironment, a prerequisite to developing new strategies targeting T cell-excluding CAF. See related commentary by Sherman, p. 2501. This article is highlighted in the In This Issue feature, p. 2483.