Cytotoxicity and Antitumor Activity of Arglabin and its Derivatives.

Sergazy M Adekenov Vojtech Spiwok John A A Beutler Olga Maslova Kayrolla Dyusenbaevich Rakhimov

Published in: Open access Macedonian journal of medical sciences (2023)

When studying the antitumor activity on 60 cell lines of tumor cells (NCI60), clonogenic cells of C6 rat glioma, a high antitumor activity of some arglabin derivatives was established. The connection between the structure of arglabin derivatives and their inhibitory effect on farnesyl protein transferase, topoisomerases -I and -II was studied.

Keyphrases

induced apoptosis
structure activity relationship
oxidative stress
cell cycle arrest
cell death
endoplasmic reticulum stress
amino acid
binding protein
signaling pathway