Acotiamide affects antral motility, but has no effect on fundic motility, gastric emptying or symptom perception in healthy participants.

Acotiamide is associated with lower antral pressures after nutrient intake, whereas it has no effect on fundic pressures, GE rate and symptom perceptions in HVs. Studies in FD need to elucidate whether lower antral pressures induced by acotiamide underlie postprandial symptom improvement in FD.