AKG induces cell apoptosis by inducing reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing PI3K/AKT/mTOR-mediated autophagy in renal cell carcinoma.

Fan WuXuexia XieGuoliang LiDongping BaoHaomin LiGuohao WuYiqi LaiYaping XingPeng OuyangGuo ChenZhifeng WangCaiyong Lai

Published in: Environmental toxicology (2022)

The anti-tumor effect of AKG promotes autophagy in renal cancer cells via mediating ROS-PI3K/Akt/mTOR, and may be used as a potential anticancer drug for kidney cancer.

Keyphrases

endoplasmic reticulum stress
reactive oxygen species
induced apoptosis
renal cell carcinoma
cell death
papillary thyroid
cell proliferation
dna damage
signaling pathway
squamous cell
squamous cell carcinoma
lymph node metastasis
risk assessment
electronic health record
drug induced