Restoring vasculogenic potential of endothelial cells from diabetic patients through spheroid formation.
Charlotte E VorwaldKaitlin C MurphyJ Kent LeachPublished in: Cellular and molecular bioengineering (2018)
Compared to cells from healthy donors, sprout formation was more efficiently abrogated in HMVECs from diabetic patients by blocking matrix metalloproteinase activity. This study demonstrates a promising approach for restoring the diminished vasculogenic potential of endothelial cells in diabetic patients.