Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy.

Ada AitaDaniela BassoRoberta RamondaStefania MozMariagrazia LorenzinFilippo NavagliaCarlo-Federico ZambonAndrea PadoanMario PlebaniLeonardo Punzi

Published in: PloS one (2018)

TNFRSF1A and MEFV gene SNPs are not associated with SpA in the North-East of Italy. AS risk appears to depend not only on HLA-B27, but also on the protective TNFA haplotype -1031C/-308G. The TNFRSF1A c.625+10A>G impacts on the response to anti-TNFα therapy.

Keyphrases

rheumatoid arthritis
genome wide
disease activity
ankylosing spondylitis
copy number
gene expression
dna methylation
cell therapy
genome wide identification