Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction-Triggered Oxidative Stress.

Meixia ChenJie LiBo ZhangXiangfang ZengXiangzhou ZengShuang CaiQianhong YeGuangxin YangChangchuan YeLijun ShangShiyan Qiao

Published in: Oxidative medicine and cellular longevity (2021)

This study demonstrated that uterine insulin sensitivity impairment beginning before pregnancy resulted in implantation and fetal loss associated with oxidative stress induced by mitochondrial dysfunction.

Keyphrases

oxidative stress
diabetic rats
dna damage
pregnancy outcomes
ischemia reperfusion injury
induced apoptosis
high glucose
preterm birth
pregnant women
drug induced
endothelial cells
signaling pathway