MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation, migration, invasion and apoptosis by regulating gene expression. In malignant tumors, miRNA‑122 serves either as a tumor suppressor or oncogene, influencing tumor progression via downstream gene targeting. However, the precise role of miRNA‑122 in cancer remains unclear. miRNA‑122 is a potential biomarker and modulator of radiotherapy and chemotherapy. The present review aimed to summarize the roles of miRNA‑122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery.
Keyphrases
- papillary thyroid
- gene expression
- cancer therapy
- locally advanced
- cell proliferation
- squamous cell
- early stage
- radiation therapy
- squamous cell carcinoma
- dna methylation
- radiation induced
- oxidative stress
- childhood cancer
- cell death
- cell cycle
- rectal cancer
- endoplasmic reticulum stress
- young adults
- signaling pathway
- copy number