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Genetic heterogeneity and enrichment of variants in DNA-repair genes in ameloblastoma.

Waheed AwotoyeJoseph Craig WhittByunggil YooMidhat S FarooqiEmily G FarrowVeerasathpurush AllareddyBrad A AmendtShankar Rengasamy Venugopalan
Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2023)
The variants identified in follicular and plexiform ameloblastomas were enriched in DNA-repair genes. The observed genetic heterogeneity in these ameloblastomas may contribute to the aggressive nature and recurrence risk of these tumors.
Keyphrases
  • dna repair
  • genome wide
  • copy number
  • dna damage
  • dna methylation
  • single cell
  • dna damage response
  • bioinformatics analysis
  • genome wide identification
  • oxidative stress
  • gene expression
  • genome wide analysis
  • free survival