Genetically Guided Mediterranean Diet for the Personalized Nutritional Management of Type 2 Diabetes Mellitus.
Kalliopi GkouskouEvgenia LazouEfstathios SkoufasAristides G EliopoulosPublished in: Nutrients (2021)
The current consensus for the prevention and management of type 2 diabetes mellitus (T2DM) is that high-quality diets and adherence to a healthy lifestyle provide significant health benefits. Remarkably, however, there is little agreement on the proportions of macronutrients in the diet that should be recommended to people suffering from pre-diabetes or T2DM. We herein discuss emerging evidence that underscores the importance of gene-diet interactions in the improvement of glycemic biomarkers in T2DM. We propose that we can achieve better glycemic control in T2DM patients by coupling Mediterranean diets to genetic information as a predictor for optimal diet macronutrient composition in a personalized manner. We provide evidence to support this concept by presenting a case study of a T2DM patient who achieved rapid glycemic control when adhered to a personalized, genetically-guided Mediterranean Diet.
Keyphrases
- glycemic control
- weight loss
- type diabetes
- blood glucose
- end stage renal disease
- physical activity
- healthcare
- chronic kidney disease
- public health
- case report
- ejection fraction
- newly diagnosed
- genome wide
- copy number
- peritoneal dialysis
- insulin resistance
- mental health
- cardiovascular disease
- prognostic factors
- patient reported outcomes
- room temperature
- risk assessment
- adipose tissue
- human health
- climate change
- ionic liquid
- genome wide analysis
- loop mediated isothermal amplification