Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains.
Sylwia Joanna ChmielewskaKarol SkłodowskiJoanna DepciuchPiotr DeptułaEwelina PiktelKrzysztof FiedorukPatrycja KotPaulina PaprockaKamila FortunkaTomasz WollnyPrzemyslaw Karol WolakMagdalena Parlinska-WojtanPaul B SavageRobert BuckiPublished in: Pharmaceutics (2021)
Conjugation of CSA-131 with Au NPs by covalent bond between the COOH group from MHDA and NH3 from CSA-131 potentiates the antimicrobial activity of this ceragenin if compared to its action alone. Results validate the development of AuR NPs@CSA-131, AuP NPs@CSA-131, and AuS NPs@CSA-131 as potential novel nanoantibiotics that might effectively eradicate MDR bacteria.