Resveratrol Treatment Ameliorates Leptin Resistance and Adiposity Programed by the Combined Effect of Maternal and Post-Weaning High-Fat Diet.

Hong-Ren YuJiunn-Ming SheenMao-Meng TiaoYou-Lin TainChih-Cheng ChenI-Chun LinYun-Ju LaiChing-Chou TsaiYu-Ju LinChing-Chang TsaiKow-Aung ChangLi-Tung Huang

Published in: Molecular nutrition & food research (2019)

These results suggest that resveratrol can alleviate peripheral leptin resistance programed by the combined effect of prenatal and postnatal HF diet through epigenetic regulation of genes coding leptin and its receptor. It provides insights into a novel mechanism explaining the beneficial effects of resveratrol in obesity management.

Keyphrases

high fat diet
insulin resistance
adipose tissue
metabolic syndrome
weight loss
skeletal muscle
type diabetes
high fat diet induced
weight gain
pregnant women
physical activity
birth weight
genome wide
intensive care unit
gene expression
acute heart failure
atrial fibrillation