Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.

Ruozhi DangMingyang WangXinhui LiHaiyang WangLanxiang LiuQingyuan WuJianting ZhaoPing JiLianmei ZhongJulio LicinioPeng Xie

Published in: Journal of neuroinflammation (2022)

These findings suggest that EDA possesses potent antidepressant and anxiolytic properties through Sirt1/Nrf2/HO-1/Gpx4 axis and Gpx4-mediated ferroptosis may play a key role in this effect.

Keyphrases

oxidative stress
ischemia reperfusion injury
major depressive disorder
cell death
pi k akt
bipolar disorder
stress induced
sleep quality
cell proliferation