Cerebrospinal Creatine Kinase BB Isoenzyme: A Biomarker for Predicting Outcome After Cardiac Arrest.

Nicholas J JohnsonNassim MatinAmita SinghArielle P DavisHsuan-Chien LiaoJames A TownDavid L TirschwellMichael G NashW T LongstrethSandeep P Khot

Published in: Neurocritical care (2024)

Cerebrospinal fluid creatine kinase BB isoenzyme levels accurately predicted poor neurological outcome among CA survivors treated with TTM. The CSF CK-BB cutoff of 230 U/L optimizes sensitivity to 69% while maintaining a specificity of 100%. CSF CK-BB could be a useful addition to multimodal neurological prognostication after CA.

Keyphrases

protein kinase
growth factor
cerebrospinal fluid
cardiac arrest
recombinant human
tyrosine kinase
young adults
pain management