Toll-like receptor-4 mediated inflammation is involved in the cardiometabolic alterations induced by intermittent hypoxia.
Laureline PoulainVincent RichardPatrick LévyMaurice DematteisClaire ArnaudPublished in: Mediators of inflammation (2015)
IH induces metabolic and vascular alterations that involve TLR4 mediated inflammation. These results confirm the important role of inflammation in the cardiometabolic consequences of IH and suggest that targeting TLR4/NFκB pathway could represent a further therapeutic option for sleep apnea patients.
Keyphrases
- toll like receptor
- nuclear factor
- oxidative stress
- inflammatory response
- sleep apnea
- immune response
- end stage renal disease
- ejection fraction
- chronic kidney disease
- lps induced
- signaling pathway
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- obstructive sleep apnea
- positive airway pressure
- pi k akt
- patient reported