The impact of delivery mode on epigenetic changes in newborns and their health outcomes.
Zuzana TurcsányiováPetra GašparováZuzana BallováErik DosedlaPublished in: Ceska gynekologie (2024)
Recent decades have seen a notable increase in cesarean section rates. Although lifesaving, cesarean delivery is associated with an elevated risk of adverse health outcomes in newborns, including respiratory diseases, atopic disorders, obesity, diabetes, and severe autoimmune conditions. The exact mechanisms underlying these associations remain elusive; however, epigenetic modifications have emerged as a plausible molecular basis linking perinatal factors with future disease susceptibility. This review summarizes current literature, revealing that the delivery method may influence epigenetic markers in neonates, primarily through alterations in global DNA methylation and gene-specific methylation patterns.
Keyphrases
- dna methylation
- genome wide
- gene expression
- pregnant women
- low birth weight
- type diabetes
- copy number
- metabolic syndrome
- gestational age
- cardiovascular disease
- insulin resistance
- cord blood
- systematic review
- multiple sclerosis
- weight loss
- preterm infants
- early onset
- emergency department
- density functional theory
- skeletal muscle
- drug induced
- current status
- glycemic control
- preterm birth
- adipose tissue
- body mass index
- adverse drug
- respiratory tract