Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer's Disease, Diabetes, and Obesity.
Giulia RigottoEmy BassoPublished in: Oxidative medicine and cellular longevity (2019)
Metabolic disorders are severe and chronic impairments of the health of many people and represent a challenge for the society as a whole that has to deal with an ever-increasing number of affected individuals. Among common metabolic disorders are Alzheimer's disease, obesity, and type 2 diabetes. These disorders do not have a univocal genetic cause but rather can result from the interaction of multiple genes, lifestyle, and environmental factors. Mitochondrial alterations have emerged as a feature common to all these disorders, underlining perhaps an impaired coordination between cellular needs and mitochondrial responses that could contribute to their development and/or progression.
Keyphrases
- type diabetes
- metabolic syndrome
- insulin resistance
- oxidative stress
- weight loss
- cardiovascular disease
- genome wide
- glycemic control
- healthcare
- cognitive decline
- public health
- weight gain
- machine learning
- mental health
- physical activity
- gene expression
- health information
- adipose tissue
- body mass index
- early onset
- risk assessment
- copy number
- mild cognitive impairment