Activation of Platelet mTORC2/Akt Pathway by Anti-β2GP1 Antibody Promotes Thrombosis in Antiphospholipid Syndrome.
Zihan TangHui ShiChangming ChenJialin TengJing DaiXinxing OuyangHong-Lei LiuQiong-Yi HuXiaobing ChengJunna YeYutong SuYue SunHaoyu PanXuefeng WangJunling LiuBing SuChengde YangYanyan XuTingting LiuPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
This study elucidated the novel mechanism involving the mTORC2/Akt pathway, which mediates the promotion of platelet activation and induction of thrombosis by the anti-β2GP1 antibody. The findings suggest that SIN1 may be a promising therapeutic target for the treatment of APS.