VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome.

Alberto LleóMaria Carmona-IraguiLaura VidelaSusana FernándezBessy BenejamJordi PeguerolesIsabel BarroetaMiren AltunaSilvia ValldeneuMei-Fang XiaoDesheng XuRaúl Núñez-LlavesMarta Querol-VilasecaSònia SirisiAlexandre BejaninM Florencia IulitaJordi ClarimónRafael BlesaPaul WorleyDaniel AlcoleaJuan ForteaOlivia Belbin

Published in: Alzheimer's research & therapy (2021)

These data show proof-of-concept for CSF VAMP-2 as a potential marker of synapse degeneration that correlates with CSF AD and axonal degeneration markers and cognitive performance.

Keyphrases

cerebrospinal fluid
cognitive impairment
spinal cord injury
electronic health record
cognitive decline
big data
human health
machine learning
risk assessment
climate change