Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.
Catherine E LovegroveJelena BeševićAkira WibergBenjamin LaceyThomas J LittlejohnsNaomi E AllenMichelle GoldsworthyJihye KimFadil M HannanCarmen LefaucheurBenjamin W TurneyMark I McCarthyAnubha MahajanRajesh V ThakkerMichael V HolmesDominic FurnissSarah A HowlesPublished in: Journal of the American Society of Nephrology : JASN (2023)
Our study indicates that visceral adipose depots elevate serum calcium concentrations, resulting in increased risk of kidney stone disease. These findings highlight the importance of weight loss in individuals with recurrent kidney stones and suggest that therapies targeting adipose depots may affect calcium homeostasis and contribute to prevention of kidney stone disease.