Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.
Henrik H HansenHelene M ÆgidiusDenise OróSimon S EversSara HeebøllPeter Lykke EriksenKaren Louise ThomsenAnja BengtssonSanne S VeidalMichel FeighMalte P SuppliFilip K KnopHenning GrønbækDiego MirandaJames L TrevaskisNiels VrangJacob JelsingKristoffer T G RigboltPublished in: BMC gastroenterology (2020)
The GAN DIO-NASH mouse model demonstrates good clinical translatability with respect to the histopathological, transcriptional and metabolic aspects of the human disease, highlighting the suitability of the GAN DIO-NASH mouse model for identifying therapeutic targets and characterizing novel drug therapies for NASH.