Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury.
Doğuş HemşinliLevent TumkayaSaban ErgeneSedat Ozan KarakişiTolga MercantepeAdnan YilmazPublished in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2022)
This study is the first to address the effects of DMT on the lung in a ruptured abdominal aortic aneurysm model. Our findings suggest that the alpha-2 adrenergic receptor agonist DMT reduces oxidative stress and apoptosis, thus protecting against aortic occlusion-induced pulmonary injury.
Keyphrases
- oxidative stress
- abdominal aortic aneurysm
- diabetic rats
- ischemia reperfusion injury
- aortic valve
- dna damage
- induced apoptosis
- pulmonary artery
- left ventricular
- pulmonary hypertension
- aortic dissection
- high glucose
- endoplasmic reticulum stress
- cardiac surgery
- cell death
- endothelial cells
- drug induced
- signaling pathway
- stress induced
- pi k akt