Phomretones A-F, C 12 polyketides from the co-cultivation of Phoma sp. YUD17001 and Armillaria sp.

Six new C 12 polyketides, phomretones A-F (1-6), were isolated from the co-culture of Armillaria sp. and the endophytic fungus Phoma sp. YUD17001 associated with Gastrodia elata . Neither fungus produced these compounds when cultured alone. The structures of 1-6 were established on the basis of comprehensive spectroscopic analyses, while their absolute configurations were determined by the comparsion of experimental and calculated ECD spectra. Compounds 2-4 are diastereoisomers of each other and featured high levels of stereoisomerization and oxidation.