RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio.
Madhu Sudhana SaddalaAnton LennikovAdam BourasHu HuangPublished in: BMC genomics (2020)
Our data strongly indicate that, among these genes, the above-mentioned pathways' genes as well as calcium-binding, neural damage, peptidase, immunological, and apoptosis proteins are mostly involved in the retinal and neural degeneration that cause abnormalities in photoreceptors or retinal pigment epithelium (RPE) cells.
Keyphrases
- rna seq
- cell cycle arrest
- single cell
- optical coherence tomography
- induced apoptosis
- diabetic retinopathy
- oxidative stress
- genome wide
- cell death
- endoplasmic reticulum stress
- bioinformatics analysis
- optic nerve
- genome wide identification
- pi k akt
- electronic health record
- big data
- signaling pathway
- transcription factor
- cell proliferation
- artificial intelligence
- data analysis