Myxoid cutaneous tumors: a review.

Unified by the common finding of myxoid background, the group of myxoid cutaneous tumors comprises many entities with different lineages, immunohistochemical profiles, underlying genetic abnormalities and biologic behaviors. These tumors may have significant histopathologic overlap causing diagnostic difficulty. Careful attention to subtle histopathologic features is key to accurate diagnosis. Immunohistochemical stains and molecular tests are valuable in selected cases. This review discusses selected myxoid tumors and myxoid variants of cutaneous tumors and focuses on key pathologic features and an effective strategy for the use of ancillary tests.