Thermo-Responsive Polymer-siRNA Conjugates Enabling Artificial Control of Gene Silencing around Body Temperature.

Yuto HondaSayaka OnoderaHiroyasu TakemotoNoor Faizah Che HarunTakahiro NomotoMakoto MatsuiKeishiro TomodaYudi SunYutaka MiuraNobuhiro Nishiyama

Published in: Pharmaceutical research (2022)

By fine-tuning the LCST behavior of the copolymer that was conjugated with siRNA, siRNA activity could be controlled in a thermo-responsive manner around the body temperature. This technique may offer a promising approach to induce therapeutic effects of siRNA selectively in the target site even in the in vivo conditions.

Keyphrases

cancer therapy
drug delivery
hyaluronic acid
photodynamic therapy
drug release