Intravenous recombinant cerebellin 1 treatment restores spinal glutamate delta 1 receptor signaling and mitigates chronic pain.

Siddhesh S SabnisKishore Kumar S NarasimhanPoojashree B ChettiarSukanya G GakareGajanan P ShelkarDevansh G AsatiShriti S ThakurShashank M Dravid

Published in: British journal of pharmacology (2023)

Together, our study demonstrates a novel mechanism by which systemic Cbln1 produces analgesia potentially by central mechanism involving normalization of spinal cord GluD1 signaling.

Keyphrases

spinal cord
chronic pain
pain management
spinal cord injury
neuropathic pain
high dose
ultrasound guided
combination therapy
low dose
postoperative pain