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Soluble MICA in endometriosis pathophysiology: Impairs NK cell degranulation and effector functions.

Maria Lucia Carnevale MarinMarici Rached RachedSandra Maria MonteiroJorge Elias Kalil FilhoMauricio Simões AbrãoVerônica Coelho
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)
We suggest that soluble MICA is a potential player in endometriosis pathophysiology with involvement in disease progression and severity, contributing to NK cell impaired IFN-γ response and degranulation. NK cell compartment exhibits multiple perturbations, including quantitative deficiency and impaired cytotoxicity, contributing to inadequate elimination of ectopic endometrial tissue.
Keyphrases
  • nk cells
  • dendritic cells
  • immune response
  • high resolution
  • regulatory t cells
  • endometrial cancer