Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats.
Fatemeh AghaieFatemeh MoradifarAbdolkarim HosseiniPublished in: Fundamental & clinical pharmacology (2021)
Our results showed that the inhibitory effect of mTOR inhibitor (rapamycin) on reactive oxygen species production during NLRP3 inflammasome activation could bring about behavioral alterations in anxiety and depression.