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Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing.

Silvia I SardiSneha SomasekarSamia N NaccacheAntonio C BandeiraLaura B TauroGubio S CamposCharles Y Chiu
Published in: Journal of clinical microbiology (2016)
Metagenomic next-generation sequencing (mNGS) of samples from 15 patients with documented Zika virus (ZIKV) infection in Bahia, Brazil, from April 2015 to January 2016 identified coinfections with chikungunya virus (CHIKV) in 2 of 15 ZIKV-positive cases by PCR (13.3%). While generally nonspecific, the clinical presentation corresponding to these two CHIKV/ZIKV coinfections reflected infection by the virus present at a higher titer. Aside from CHIKV and ZIKV, coinfections of other viral pathogens were not detected. The mNGS approach is promising for differential diagnosis of acute febrile illness and identification of coinfections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.
Keyphrases
  • zika virus
  • aedes aegypti
  • dengue virus
  • copy number
  • sars cov
  • liver failure
  • antibiotic resistance genes
  • respiratory failure
  • drug induced
  • gene expression
  • dna methylation
  • acute respiratory distress syndrome