Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice.

Dongyang Jiang Hao LiuGuofu ZhuXiankai LiLinlin FanFaxue ZhaoChong XuShumin WangYara RoseJordan RhenZe YuYiheng YinYuling GuXiangbin XuEdward A Fisher Jun-Bo Ge Yawei Xu Jinjiang Pang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our results identified endothelial PHACTR1 as a novel PPARγ corepressor to promote atherosclerosis in disturbed flow regions. Endothelial PHACTR1 is a potential therapeutic target for atherosclerosis treatment.

Keyphrases

endothelial cells
cardiovascular disease
insulin resistance
type diabetes
replacement therapy
smoking cessation
human health