Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11-CCR3 pathway.

S BekaertN RocksC VanwingeA NoelDidier Cataldo

Published in: Respiratory research (2021)

Allergic inflammation generated by exposure to allergens triggers the implantation of metastatic cells from primary breast tumor into lung tissues plausibly in a CCL11-CCR3-dependent manner. This indicates that asthma related inflammation in lungs might be a risk factor for lung metastasis in breast cancer patients.

Keyphrases

oxidative stress
chronic obstructive pulmonary disease
breast cancer cells
allergic rhinitis
lung function
squamous cell carcinoma
dendritic cells
regulatory t cells
small cell lung cancer
gene expression
liver fibrosis
air pollution