Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity.

I MatiasE W LehmannP ZizzariS BybergD CotaS S TorekovCarmelo Quarta

Published in: Journal of endocrinological investigation (2023)

Our data suggests that specific NAEs such as OEA and AEA are promising biomarkers of GLP-1RA metabolic efficacy in humans with obesity during weight loss maintenance. Plasma profiling of EC-related molecules may be a promising strategy to tailor GLP-1R-based therapies to individual needs in obesity and diabetes management.

Keyphrases

weight loss
type diabetes
insulin resistance
bariatric surgery
metabolic syndrome
high fat diet induced
weight gain
roux en y gastric bypass
glycemic control
gastric bypass
cardiovascular disease
rheumatoid arthritis
adipose tissue
electronic health record
big data
systemic lupus erythematosus