Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus.
Andrea Navas-OliveRodrigo AmaducciMaria-Teresa Jurado-ParrasEnrique R SebastianLiset Menendez de la PridaPublished in: eLife (2022)
Local field potential (LFP) deflections and oscillations define hippocampal sharp-wave ripples (SWRs), one of the most synchronous events of the brain. SWRs reflect firing and synaptic current sequences emerging from cognitively relevant neuronal ensembles. While spectral analysis have permitted advances, the surge of ultra-dense recordings now call for new automatic detection strategies. Here, we show how one-dimensional convolutional networks operating over high-density LFP hippocampal recordings allowed for automatic identification of SWR from the rodent hippocampus. When applied without retraining to new datasets and ultra-dense hippocampus-wide recordings, we discovered physiologically relevant processes associated to the emergence of SWR, prompting for novel classification criteria. To gain interpretability, we developed a method to interrogate the operation of the artificial network. We found it relied in feature-based specialization, which permit identification of spatially segregated oscillations and deflections, as well as synchronous population firing typical of replay. Thus, using deep learning-based approaches may change the current heuristic for a better mechanistic interpretation of these relevant neurophysiological events.
Keyphrases
- deep learning
- cerebral ischemia
- high density
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- artificial intelligence
- convolutional neural network
- machine learning
- prefrontal cortex
- working memory
- high resolution
- bioinformatics analysis
- optical coherence tomography
- cognitive impairment
- mild cognitive impairment
- human health
- cognitive decline
- risk assessment
- mass spectrometry
- magnetic resonance
- climate change
- rna seq
- resting state
- functional connectivity
- single cell
- dual energy
- real time pcr